The NPIAP (The National Pressure Injury Advisory Panel) Position Statement was made in collaboration with the European Pressure Ulcer Advisory Panel (EPUAP) and the Pan Pacific Pressure Injury Alliance (PPPIA). The NPIAP, along with these other expert panels, developed “an evidence-based guideline” to help prevent pressure injuries caused by N95 masks. This position statement is unique in that it combines current evidence in both pressure injury prevention and PPE science as a basis for recommendations within the context of the COVID-19 crisis.